Younus Khan became just the third Pakistan batsman to pass 8,000 Test runs on another run-laden day at Abu Dhabi.
The 36-year-old joined Javed Miandad and Inzamam-ul-Haq in passing the feat as he completed his fifth Test double century, while Misbah-ul-Haq added 101 as Pakistan declared on 570 for six on the second day of the second Test.
Australia lost Chris Rogers cheaply as they finished the day on 22 for one.
Despite Pakistan starting on 304 for two, the day had begun brightly for the visitors, with Mitchell Starc removing overnight centurion Azhar Ali in the 10th over of the day for 110, caught down the legside by stand-in wicketkeeper David Warner.
Warner had earlier taken the gloves after Brad Haddin was forced off after hurting his shoulder while sprawling for a catch.
The opening batsman missed a golden opportunity almost immediately as Younus advanced down the track, but the keeper was unable to gather the ball in.
Misbah and Younus added 181 for the fourth wicket before Steve Smith finally got the breakthrough shortly before tea.
The Pakistan captain pushed forward lazily and popped a simple return catch to the leg-spinner, who was less than impressed when a review was called to determine whether the catch was clean.
Australia were unable to keep a lid on the scoring however, with the red-hot Younus dominant against the spin of Glenn Maxwell and Nathan Lyon, who both proved to be expensive.
With the hosts looking the push the scoring rate along after tea, Younus finally perished for 213 after Peter Siddle sent his middle stump flying as he attempted a wild heave across the line.
Asad Shafiq played on to Starc for 21 before the declaration was finally called with the score on 570 for six, leaving Australia with 12 overs to bat out before the close.
After a positive start, Rodgers edged a good delivery by Imran Khan behind for five and it was left to nightwatchman Lyon to see out the remaining overs.
Australia will start the second day 548 runs in arrears and facing their first series defeat to Pakistan since 1994.